The far carboxy-terminus of the viral encoded chemokine receptor US28 binds to the sorting protein GASP-1 in vitro
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چکیده
منابع مشابه
The far carboxy-terminus of the viral encoded chemokine receptor US28 binds to the sorting protein GASP-1 in vitro
US28 is a chemokine receptor encoded by the human cytomegalovirus (hCMV) and seems to be crucial for viral propagation. It is a constitutively active receptor. For instance it was shown that US28 signals via Gq/PLC and activates the transcription factors nuclear factor κB (NFκB), cyclic AMP response element binding protein (CREB) and nuclear factor of activated T-cells (NFAT). Hence, the recept...
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Address: 1Institute of Experimental and Clinical Pharmacology, Medical University of Graz, 8010 Graz, Austria , 2Ernest Gallo Clinic and Research Center, University of California San Francisco, CA 94608, USA, 3Leiden/Amsterdam Center for Drug Research (LACDR), Division of Medicinal Chemistry, Faculty of Sciences, VU University Amsterdam, 1081 HV Amsterdam, The Netherlands and 4Department of Der...
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Human cytomegalovirus, which infects up to 80% of the general population, causes severe complications in immunocompromised patients and is thought to be linked to vascular diseases, such as atherosclerosis and restenosis. This β-herpesvirus encodes a G protein-coupled receptor (GPCR), namely US28, which does not only show homology to endogenous chemokine receptors but also binds endogenous CC c...
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ژورنال
عنوان ژورنال: BMC Pharmacology
سال: 2008
ISSN: 1471-2210
DOI: 10.1186/1471-2210-8-s1-a26